Journal of Integrative Dermatology
type: channel
description: The Journal of Integrative Dermatology publishes information concerning the skin and external and internal factors that modulate its function, health, and disease. The Journal of Integrative Dermatology is an international, peer-reviewed, open-access journal committed to the highest standards of rigor and relevance spanning multidisciplinary fields represented in integrative dermatology, including but not limited to conventional treatments and pharmaceuticals, naturopathic medicine, ayurveda, energy medicine, lifestyle medicine, nutrition, microbiome, gut health, functional medicine, and traditional Chinese medicine. The Journal of Integrative Dermatology is the first of its kind, expanding the rigorous evidence around interdisciplinary modalities in cutaneous science.
language: en
publication name: Journal of Integrative Dermatology
items: Clay Therapy in Wound Care: A Scientific Review of Bentonite and Kaolinite Clays and Their Antimicrobial Potentials
items: Reversal of Severe Facial Acne by a Low Carbohydrate, Ketogenic Diet
items: Understanding Barriers and Attitudes Towards Dietary Intervention Use in the Management of Eczema: A Survey Study
items: A review of the dermatologic activity and applications of Centella asiatica
items: Emerging Interest in Red Light Therapy for Skin Rejuvenation: A Google Trends Analysis
items: Liquid Gold: A review of the dermatologic applications of honey
items: Cross-Sectional Survey Study Addressing Dermatologist Perspectives on Wearable Devices
items: Hormetic Stimulation and its Potential Health benefits for Skin
items: Dietary and Microbiome-Directed Adjuncts in Atopic Dermatitis: Prebiotics, Probiotics, Synbiotics, and Parabiotics
items: Open Label Pilot Study on the Combination of an Oral Pre- and Pro-biotic, a Biotech Botanical Moisturizer and Unscented Soap in Moderate Atopic Dermatitis
items: Effect of tralokinumab treatment in patients with moderate-to-severe atopic dermatitis and allergy-related conditions
items: From Phytochemicals to Nanocosmeceuticals: Green Nanocarriers for Anti-Inflammatory and Antioxidant Skin Therapy
items: Five Mountains, One Summit: A Framework for Product Success
items: From Vectors to Vulnerability: Climate Change’s Role in Dermatology
items: Introduction of Oral Probiotics for Symptom Reduction in Pediatric Atopic Dermatitis: A Prospective Pilot Study
items: Hidradenitis Suppurativa Subtypes: Exploring Proposed Phenotypes and Their Clinical Relevance
items: Beyond Hot Flashes: Understanding and Treating Menopause-Associated Skin Changes
items: Cyano-Phycocyanin: A Potential Photoprotective Nutraceutical to Reduce Ultraviolet Radiation-Induced Damage and Skin Cancer Risk
items: Reframing Dermatologic Disease Through Trauma, Attachment, and Autonomic Science: An Integrated Biopsychosocial Framework for Clinical Practice
items: Calming the Itch: Evidence-Based Non-pharmacologic Interventions for Chronic Pruritus
items: One Oral Dermatologic Supplement with Two Indications? A Review of Active Ingredients in Popular Hair Supplements and Their Efficacy in Treating Hair Loss and Acne
items: An Overview of Hyperhidrosis Treatment Options with an Emphasis on Iontophoresis as a Non-invasive, Effective, and Safe Treatment Modality
items: https://dev.jintegrativederm.org/index.php/joid/article/view/134
items: From the Kitchen to Your Skin: A Review of Nontraditional Moisturizers
items: Insulin resistance in Mexican women with acne vulgaris
items: Indigo Naturalis in Dermatology: Current Evidence and Clinical Applications
items: Healing from the Desert: Southwestern U.S. Indigenous Botanicals for Inflammatory Skin Conditions
items: The Impact of Social Media Influencers on Skincare Behaviors Among Skin of Color Populations: A Narrative Review (2015-2025)
items: Practical Pain-Free Dermatology: A Review of Evidence-Based Approaches to Minimizing Procedural Discomfort
items: Milk and Skin: A Narrative, Integrative Review of Dairy and Dairy Substitutes Through the Lens of Cutaneous Inflammation

Clay Therapy in Wound Care: A Scientific Review of Bentonite and Kaolinite Clays and Their Antimicrobial Potentials
type: item
description: Mineral-rich clays, particularly bentonite and kaolinite, have been utilized for centuries by Indigenous communities across North America, South America, Africa, and Australia for wound healing and managing infections. Contemporary scientific research increasingly validates these traditional practices, confirming that these clays exhibit broad-spectrum antimicrobial activity, notably against antibiotic-resistant pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. The antimicrobial efficacy of bentonite and kaolinite arises through multiple mechanisms, including the release of bioactive metal ions (e.g., iron, copper, zinc), pH modulation creating an inhospitable environment for microbes, toxin adsorption limiting microbial proliferation, and the generation of reactive oxygen species (ROS) that compromise bacterial cellular integrity. Despite their demonstrated therapeutic potential, significant gaps persist, including variability in clay composition, limited standardized clinical evaluations, and insufficient regulatory frameworks. This review synthesizes existing literature on the antimicrobial mechanisms, therapeutic efficacy, and potential risks associated with bentonite and kaolinite in wound management. Furthermore, it highlights the necessity of integrating Indigenous medicinal knowledge with modern microbiological and dermatological research to facilitate the development of standardized, clinically effective clay-based therapies. Addressing these knowledge gaps could enable innovative, sustainable approaches to wound care and contribute meaningfully to global efforts combating antimicrobial resistance.
subject: Review Article
  topic: section
subject: Natural antimicrobials
  topic: keywords
subject: pH modulation
  topic: keywords
subject: Dermatologic therapy
  topic: keywords
subject: Antibacterial clay
  topic: keywords
subject: Bentonite
  topic: keywords
subject: Kaolinite
  topic: keywords
subject: Montmorillonite
  topic: keywords
subject: Metal ion toxicity
  topic: keywords
subject: Wound care
  topic: keywords
subject: Dermatologic infections
  topic: keywords
creator: Andres D. Parga, MD
creator: Vivian Mendoza-Leon, BS
creator: Shane Ganga, M.D, MBA
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-08-17
publication date: 2026-08-17
doi: 10.64550/joid.24e4zd41

Reversal of Severe Facial Acne by a Low Carbohydrate, Ketogenic Diet
type: item
description: Acne vulgaris affects more than 50% of adults in the United States. The major recognized pathological processes in the development of acne are increased sebum production by the sebaceous gland, altered keratinization of follicular keratinocytes, activity of Cutibacterium acnes, and inflammation. Despite advancements in treatment, overall acne prevalence continues to increase as well as cases of acne refractory to standard therapies. Many patients have shifted their focus away from medications and procedures to solve their ailments and are focused on addressing the “root causes.” Does diet play more of a role than we previously thought? Are our modern foods inherently inflammatory? Is inflammatory acne that responds to low-carbohydrate diets secondary to insulin resistance or weight loss? In this report, we describe a case of rapid resolution of severe cystic acne using a low-carbohydrate, ketogenic diet.
subject: Case Study/Case Series
  topic: section
subject: ketogenic diet
  topic: keywords
subject: Acne vulgaris
  topic: keywords
subject: Dermatology
  topic: keywords
subject: metabolic health
  topic: keywords
subject: inflammatory
  topic: keywords
creator: Kathryn Keller, BS
creator: Catherine Barker, MD
creator: Eric C. Westman, MD, MHS
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-08-05
publication date: 2026-08-05
doi: 10.64550/joid.njzfz727

Understanding Barriers and Attitudes Towards Dietary Intervention Use in the Management of Eczema: A Survey Study
type: item
description: # Relevance Special dietary intervention use, including Mediterranean among other diets to manage eczema is limited, though it has been studied among psoriasis patients. # Objective Our prospective survey study aims to assess differences in demographics, barriers, and attitudes between eczema patients initiating and not initiating a special dietary intervention. # Methods 71 eczema patients at a dermatology clinic at the University of Pittsburgh Medical Center were surveyed one time at their visit, after obtaining informed consent using the REDCap platform. Inclusion criteria included adult patients with a clinical diagnosis of eczema. Data was analyzed using IBM SPSS software with a significance level of 0.05. # Results 24 patients (33.8%) tried a special dietary intervention. This cohort was frequently younger (36.09 vs. 47.79 years; p=0.013), had an eczema flare more than one year ago (16.7% vs. 2.1%; p=0.042), and tried dietary additions including vegetables (23.0% vs. 10.3%; p<0.001), fruits (23.0% vs. 13.2%; p<0.001), water (26.2% vs. 16.2%; p<0.001), and fish (18.0% vs. 8.8%; p=0.002). Dietary eliminations including dairy (25.9% vs. 15.8%; p=0.025) and gluten (29.6% vs. 0%; p<0.001) were more common among this cohort. There were no differences in social, familial, and financial barriers between the two groups. However, belief that special diets are beneficial for skin disease (70.8% vs. 42.6%; p=0.024), that diet has a major effect on skin disease management (20.8% vs. 4.3%; p=0.040), that lifestyle interventions are preferred over medications (83.3% vs. 46.8%; p=0.003), and that physicians should discuss dietary intervention in eczema management (79.2% vs. 55.3%; p=0.048) was higher among special dietary intervention users. # Conclusion Special dietary intervention users were younger, frequently tried dietary additions and eliminations, and had more positive attitudes about dietary intervention efficacy. This study highlights the need for greater awareness a…
subject: Original Research
  topic: section
subject: diet
  topic: keywords
subject: Integrative Dermatology
  topic: keywords
subject: intervention
  topic: keywords
subject: barriers
  topic: keywords
subject: Eczema
  topic: keywords
creator: Vrusha K Shah, MPH
creator: Alana Sadur, BS
creator: Alejandra Curbelo-Paz, BS
creator: Sonal Choudhary, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-07-24
publication date: 2026-07-24
doi: 10.64550/joid.y8rjf954

A review of the dermatologic activity and applications of Centella asiatica
type: item
description: *Centella asiatica* (also known as cica or Gotu Kola) is a medicinal herb in the Apiaceae family, long used in Ayurvedic, Chinese, and Unani medicinal traditions for wound healing and treatment of skin conditions. Its active compounds—asiaticoside, madecassoside, asiatic acid, and madecassic acid—have demonstrated anti-inflammatory, antioxidant, and regenerative effects, making it an increasingly popular ingredient in dermatology and skin care products. To summarize its current role in skin health, we performed a literature review over the past decade using PubMed and Google Scholar. Search terms included “Centella asiatica,” “Gotu Kola,” “cica,” “skin,” “wound healing,” and “dermatology.” Preclinical and early clinical data indicate that *C. asiatica* enhances fibroblast proliferation, collagen synthesis, and angiogenesis, thereby improving healing in acute wounds, chronic ulcers, and surgical scars, while reducing hypertrophic and keloid scar formation. *C. asiatica* also demonstrated anti-inflammatory and antioxidant activity, mediated through NF-κB, JAK/STAT, COX-2, and LOX pathways, suggesting a role in the management of acne, rosacea, psoriasis, and photoaging. Aesthetic applications include striae and anti-aging therapies, with studies reporting improvements in pigmentation, elasticity, and fine lines. Recent small studies also suggest potential benefits for hair loss and vitiligo through follicle stimulation and melanocyte protection. Topical *C. asiatica* is generally well tolerated. Adverse reactions are uncommon, with rare case reports describing allergic contact dermatitis after use. Although larger-scale clinical studies are needed, existing evidence suggests that *C. asiatica* is a versatile and well-tolerated botanical with growing importance in dermatology and skin care.
subject: Review Article
  topic: section
subject: Centella asiatica
  topic: keywords
subject: Gotu kola
  topic: keywords
subject: CICA
  topic: keywords
subject: striae
  topic: keywords
subject: wound-healing
  topic: keywords
subject: Dermatology
  topic: keywords
creator: Natalie M. Soliman, BS
creator: Maithili Bhagat, MBA
creator: Alejandra Segarra Ponce, MD
creator: Andrea M. Rustad, MD
creator: Trisha Khanna, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-07-21
publication date: 2026-07-21
doi: 10.64550/joid.mjyk2r15

Emerging Interest in Red Light Therapy for Skin Rejuvenation: A Google Trends Analysis
type: item
description: Skin rejuvenation is an expanding field of cosmetic science with increasing demand for non-invasive options. Red light therapy (RLT), or photobiomodulation, has gained popularity due to its accessibility, favorable safety profile, and relatively low cost compared to other procedures. This study used Google Trends (GT) to evaluate public interest in RLT compared with tretinoin, platelet-rich plasma (PRP), and radiofrequency ablation (RFA) from June 2020 to June 2025. GT assigns normalized values reflecting relative search frequency. Linear regression showed the greatest increase in search frequency for “red light therapy” (slope = +0.0355), surpassing tretinoin (+0.0205), PRP (+0.0003), and RFA (+0.0002). ANCOVA confirmed a statistically significant difference in the rate of change (p = 2.33 × 10⁻²⁶¹), with RLT also maintaining the highest average search volume. Geospatial analysis demonstrated peak interest in Idaho, Utah, Hawaii, Arizona, and Colorado. RLT acts via red and near-infrared wavelengths to stimulate mitochondrial activity, enhance ATP production, and promote dermal remodeling. Despite clinical evidence of efficacy, variation among consumer devices raises concerns about reproducibility and safety. The surge in public interest underscores the need for clinicians to counsel patients on expectations, safety, and device differences, as well as the importance of establishing standardized guidelines to ensure safe and effective outcomes.
subject: Concise Communication
  topic: section
subject: red light therapy
  topic: keywords
subject: skin rejuvenation
  topic: keywords
subject: Google Trends
  topic: keywords
subject: photobiomodulation
  topic: keywords
subject: non-invasive aesthetics
  topic: keywords
creator: Nicholas Belair, BS
creator: Meghan Mansour, MD
creator: Kongkrit Chaiyasate, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-07-10
publication date: 2026-07-10
doi: 10.64550/joid.dmhnwj22

Liquid Gold: A review of the dermatologic applications of honey
type: item
description: Honey has been used for centuries for a variety of medicinal purposes, including wound healing and mucocutaneous conditions. Modern research has elucidated many of the biochemical mechanisms behind its efficacy in dermatologic conditions. This manuscript outlines the proposed scientific mechanisms behind honey’s antimicrobial, wound healing, and anti-inflammatory effects and its applications in dermatology. As interest in integrative and natural therapies grows, honey continues to emerge as a relevant natural alternative or adjunctive treatment for multiple dermatologic conditions. Topical honey is promising as an overall safe, affordable, and effective treatment in dermatology and wound care. However, more research is needed to define its medicinal use and to determine optimal treatment protocols.
subject: Review Article
  topic: section
subject: honey
  topic: keywords
subject: Integrative Dermatology
  topic: keywords
subject: wound care
  topic: keywords
subject: inflammatory dermatoses
  topic: keywords
subject: natural treatments
  topic: keywords
subject: Manuka honey
  topic: keywords
creator: Natalie M Soliman, BS
creator: Andrea M Rustad, MD
creator: Apple Bodemer, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-07-06
publication date: 2026-07-06
doi: 10.64550/joid.ccgp2m09

Cross-Sectional Survey Study Addressing Dermatologist Perspectives on Wearable Devices
type: item
description: # Relevance Wearable devices are noninvasive tools that continuously capture physiological data such as temperature, heart rate variability, and sleep cycles. In dermatology, wearables can assess parameters including pruritus, hydration, and skin biomarkers, which impact conditions such as atopic dermatitis and psoriasis. While clinician perspectives on wearables in other inflammatory diseases have been explored, little is known about how dermatologists view these technologies. # Methods We conducted a cross-sectional, 13-question survey of dermatologists and trainees at a national dermatology conference. The survey, adapted from a validated instrument, included multiple-choice and Likert-scale questions (0–4 scale, 0 = poor, 4 = excellent). Four demographic questions were followed by nine questions targeting gaps in awareness, education, and clinical adoption of wearables. Participants were recruited opportunistically from a booth. Data were analyzed using descriptive statistics. # Results A total of 60 respondents completed the survey (100% response rate). Participants were predominantly aged 30–39 years (50%), identified as women (54.2%), and were residents or fellows (42.4%). Most respondents (87.6%) considered physician knowledge of wearables important and believed peer-reviewed literature was the most trusted information source (38.6%). Familiarity with wearables was low, with 51.9% rating themselves at the lowest levels (0–1). While fitness trackers were the most recommended devices (51.7%), 34.6% of respondents lacked confidence in educating patients about wearables and 43.1% of dermatologists reported they were not planning to change their behaviors in the next six months to include wearables during patient education. Cost (45.0%) and lack of training (43.3%) were the most frequently reported barriers to integration. Lastly, 75.4% indicated that wearable data were not integrated into electronic health records. # Discussion Dermatology providers recognize th…
subject: Concise Communication
  topic: section
subject: Wearable
  topic: keywords
subject: wearable monitor
  topic: keywords
subject: digital health
  topic: keywords
subject: Barrier repair
  topic: keywords
subject: dermatology
  topic: keywords
subject: dermatologist
  topic: keywords
subject: technology
  topic: keywords
creator: Hannah Gandy
creator: Hannah Neimy
creator: Penny Smith, MS
creator: Shelby Smith
creator: Mary Nan Leath
creator: Milaan Shah, MD
creator: Angela Rosenberg, DO
creator: Lauren DeBusk, MD
creator: Zachary K. Winkelmann, PhD, LAT, ATC, CHSE
creator: Alexander V. Alekseyenko, PhD
creator: Manuel Valdebran, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-06-30
publication date: 2026-06-30
doi: 10.64550/joid.83ch4r52

Hormetic Stimulation and its Potential Health benefits for Skin
type: item
description: Numerous treatment strategies have been proposed to slow the aging process or mitigate its detrimental effects. Hormesis, or hormetic stimulation, refers to the process by which mild and controlled stressors induce adaptive and beneficial cellular responses. These stressors, ranging from plant-derived compounds to nanomaterials, can be natural, chemical, or mechanical in origin. Recent technological advances have led to the development of more targeted compounds that harness the potential of hormesis for therapeutic and cosmetic applications. In this review, we conducted a comprehensive literature search using Google Scholar, PubMed, and ScienceDirect to examine original studies on hormetic stimulation in skin cells. We highlight the roles of heat shock proteins (HSPs), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in mediating these effects. Evidence indicates that mild heat stress enhances antioxidant capacity and proteasome activity, curcumin induces Nrf2/HO-1 activation and promotes wound healing, and low-dose nanomaterials stimulate cell viability and regeneration. We also discuss the emerging application of nanomaterials in cosmetic formulations and their hormetic impact on skin health. Although the underlying mechanisms are increasingly well understood, further research is needed to clarify the clinical implications and optimize the use of hormetic agents in dermatology and anti-aging interventions.
subject: Original Research
  topic: section
subject: Curcumin
  topic: keywords
subject: Heat shock proteins
  topic: keywords
subject: Hormesis
  topic: keywords
subject: Hormetins
  topic: keywords
subject: Nrf2
  topic: keywords
creator: Saviz Saghari, MD
creator: Steven Daveluy, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-06-24
publication date: 2026-06-24
doi: 10.64550/joid.qw1fa567

Dietary and Microbiome-Directed Adjuncts in Atopic Dermatitis: Prebiotics, Probiotics, Synbiotics, and Parabiotics
type: item
description: # Background Microbiome-directed therapies are increasingly used by patients with atopic dermatitis (AD), yet clinical guidance remains fragmented and often extrapolated from low-quality evidence. This review synthesizes current data on dietary strategies, prebiotics, probiotics, synbiotics, and parabiotics for the treatment of AD. # Methods We performed a comprehensive literature search of PubMed/MEDLINE, Embase, Cochrane Library, and ClinicalTrials.gov from inception to October 2025 evaluating randomized controlled trials, mechanistic studies, and systematic reviews reporting clinical outcomes in patients with AD. Interventions were assessed for efficacy, durability, safety, age-specific effects, and strain- or formulation-specific patterns. Particular attention was given to trials using standardized severity indices and those incorporating microbiome or metabolomic profiling. # Results Evidence supporting diet-based interventions is limited: whole-food, fiber-diverse dietary patterns may confer microbiome-mediated benefits, whereas elimination diets should be restricted to confirmed IgE-mediated food allergy. Prebiotics show modest, inconsistent improvements in pediatric AD but limited effect in adults. Probiotic and synbiotic trials demonstrate strain-dependent and age-dependent outcomes, with best responses in older children and adults using high-quality, well-characterized strains. Postbiotics, though less studied, show short-term symptomatic improvements with favorable safety profiles but no sustained benefit after discontinuation. Across modalities, heterogeneity in strain selection, dosing, formulation, and outcome measures limits comparability. Mechanistic data increasingly support roles for SCFA signaling, immune modulation, and barrier effects, but results remain preliminary. # Conclusions Microbiome-directed adjuncts may provide modest, strain-specific, and age-specific benefits in treating established AD, but should not replace standard anti-inflammato…
subject: Original Research
  topic: section
subject: atopic dermatitis
  topic: keywords
subject: microbiome-directed therapy
  topic: keywords
subject: prebiotics
  topic: keywords
subject: probiotics
  topic: keywords
subject: synbiotics
  topic: keywords
subject: parabiotics
  topic: keywords
subject: diet and nutrition
  topic: keywords
creator: Isabella J. Tan, BS
creator: Melina B. Jampolis, MD, PSN, CSNC
creator: Peter Lio, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-06-09
publication date: 2026-06-09
doi: 10.64550/joid.h06meh60

Open Label Pilot Study on the Combination of an Oral Pre- and Pro-biotic, a Biotech Botanical Moisturizer and Unscented Soap in Moderate Atopic Dermatitis
type: item
description: # Relevance Atopic dermatitis (AD) is an inflammatory skin condition with a multifac-torial pathophysiology. Standard treatment emphasizes topical corticosteroids (TCs), but there is growing interest in alternatives to TCs. # Objective To evaluate the efficacy of a novel pre- and pro-biotic supplement, a biotech botanical moisturizer, and an unscented soap on AD severity, pruritic, and skin biophysical properties. # Methods The efficacy of the pre- and pro-biotic supplement were evaluated. An open label trial was conducted involving 34 subjects with moderate AD. At baseline and day 56, the SCORAD, pruritus, and skin biophysical measures were assessed. # Results Between D0 and D56, mean total SCORAD decreased by 93% (p<0.0001), mean oSCORAD decreased by 94% (p<0.0001), and mean p-NRS decreased by 92% (p<0.0001). By D56, TEWL decreased by 39% (p=0.0001), hydration increased by 115% (p<0.0001), and desquamation index decreased by 18% (p<0.005). # Conclusions The pre- and pro-biotic supplement, botanical moist-urizer, and unscented soap demonstrated improvement in skin barrier integrity and AD severity in 8 weeks, suggesting potential clinical efficacy for AD management.
subject: Original Research
  topic: section
subject: microbiome and skin health
  topic: keywords
subject: atopic dermatitis
  topic: keywords
subject: hydration and skin barrier
  topic: keywords
subject: prebiotic
  topic: keywords
subject: probiotic
  topic: keywords
subject: nutrients and dermatology
  topic: keywords
subject: nutraceutical
  topic: keywords
subject: cosmeceutical
  topic: keywords
subject: SCORAD
  topic: keywords
creator: Barbara Paldus, PhD
creator: Mark Selker, PhD
creator: Jessica Maloh, ND
creator: Izabela Blazewicz, MD
creator: Peter A. Lio, MD
creator: Marc Cornell
creator: Philippe Humbert, MD, PhD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-06-09
publication date: 2026-06-09
doi: 10.64550/joid.y9t54229

Effect of tralokinumab treatment in patients with moderate-to-severe atopic dermatitis and allergy-related conditions
type: item
description: Atopic dermatitis (AD) is a chronic inflammatory skin disease often associated with allergy-related comorbidities such as asthma, hay fever, food allergies, and eye allergies. This study evaluated the effects of tralokinumab treatment in patients with moderate-to-severe AD and coexisting allergy-related conditions. Data from four phase 3 clinical trials involving adults and adolescents with moderate-to-severe AD were analyzed over a 16-week period, comparing tralokinumab with placebo. Patients were grouped according to self-reported history of asthma, hay fever, food allergies, and eye allergies. Results showed that patients receiving tralokinumab demonstrated significant improvements in AD severity regardless of allergy history, including clearer skin and reduced disease severity. Reported side effects were generally mild to moderate and comparable to placebo. Overall, tralokinumab reduced AD severity in patients with moderate-to-severe AD, supporting its use as a treatment option for individuals with co-occurring allergy-related conditions.
subject: Perspective, Opinion, Commentary
  topic: section
subject: Atopic dermatitis
  topic: keywords
subject: Tralokinumab
  topic: keywords
subject: Atopic comorbidities
  topic: keywords
subject: Type 2 inflammation
  topic: keywords
subject: IL-13
  topic: keywords
subject: Plain language
  topic: keywords
creator: Amy S. Paller, MD
creator: Weily Soong, MD
creator: Mark Boguniewicz, MD
creator: Bob Geng, MD
creator: Jacob P. Thyssen, MD, PhD
creator: Niels Bennike, MD, PhD
creator: Shannon K. R. Schneider, PhD
creator: Andreas Wollenberg, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-05-25
publication date: 2026-05-25
doi: 10.64550/joid.3tdtzv65

From Phytochemicals to Nanocosmeceuticals: Green Nanocarriers for Anti-Inflammatory and Antioxidant Skin Therapy
type: item
description: Chronic inflammatory and oxidative stress–driven skin disorders, including acne vulgaris, atopic dermatitis, psoriasis, photoaging, and impaired wound healing, share convergent pathogenic mechanisms characterized by redox imbalance, cytokine dysregulation, and impaired barrier function. Although plant-derived phytochemicals such as flavonoids, terpenoids, phenolic acids, and alkaloids exhibit broad antioxidant, anti-inflammatory, and reparative activities across these conditions, their dermatologic translation is constrained by chemical instability, low bioavailability, and limited cutaneous penetration. Advances in green nanotechnology offer a strategy to overcome these limitations by integrating botanical pharmacology with nanoscale delivery through environmentally benign synthesis. Phytochemical-mediated nanoparticle fabrication enables plant metabolites to serve as both reducing and capping agents, yielding nanocarriers with enhanced physicochemical stability, biocompatibility, and intrinsic biologic activity. These green nanocarriers improve penetration of the epidermis and follicles, increase local retention, and enable environmentally responsive release within inflamed or oxidative skin microenvironments. Across diverse phytochemical classes, modulation of key cutaneous signaling pathways, including Nrf2–Keap1, NF-κB, MAPK, the aryl hydrocarbon receptor, and PI3K–Akt–mTOR, underlies observed effects on oxidative stress regulation, cytokine suppression, cellular proliferation, extracellular matrix remodeling, and barrier restoration. Phytochemical-rich surface coronas further contribute to antioxidant buffering, controlled release, and microenvironment-specific interactions, enhancing therapeutic precision while limiting off-target exposure. Considerations related to safety, toxicology, reproducibility, regulatory oversight, and sustainability remain central to clinical translation, particularly given the inherent variability of plant-based synthesis. Collecti…
subject: Original Research
  topic: section
subject: green nanotechnology
  topic: keywords
subject: nanocosmeceuticals
  topic: keywords
subject: oxidative stress
  topic: keywords
subject: phytochemicals
  topic: keywords
subject: topical drug delivery
  topic: keywords
creator: Cutler Cannon, MSc
creator: Diego A. Ramos-Briceño, BEng
creator: Sarah Clark Newberry, MS
creator: Raja K. Sivamani, MD, MS, AP
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-05-22
publication date: 2026-05-22
doi: 10.64550/joid.y3pyxb40

Five Mountains, One Summit: A Framework for Product Success
type: item
description: Clinician-founders function at the interface of patient care and product development. However, they often face challenges that extend beyond a single clear solution. Successful product development often emerges across many parallel domains. To address this, we propose the Five Mountains Framework, a model in which each “mountain” represents a distinct lever to manipulate during product development and deployment. Formulation, the experience lever, refers to the texture, scent, packaging, and regimen simplicity, determining whether a product is used or abandoned. Evidence, the credibility lever, reflects the clinical data supporting the utility of the product. Narrative, the meaning lever, shapes the consumer perception of the product before it is even used. Accessibility, the reach lever, converts interest into action by making the product easy to find and affordable. Education, the understanding lever, guides consumers toward confident, effective use of the product. Together, these five domains constitute the Five Mountains Framework, which represents the landscape that clinician-founders need to navigate to produce a successful product.
subject: Perspective, Opinion, Commentary
  topic: section
subject: Product development
  topic: keywords
subject: Clinician-founder
  topic: keywords
subject: Formulation
  topic: keywords
subject: Health education
  topic: keywords
subject: Accessibility
  topic: keywords
creator: Meshi Paz
creator: Peter Lio, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-05-11
publication date: 2026-05-11
doi: 10.64550/joid.9vgvdj92

From Vectors to Vulnerability: Climate Change’s Role in Dermatology
type: item
description: Climate change is a major crisis in the medical, political, and environmental realms, significantly impacting local and global health. Dermatology is not immune to the effects of climate change, yet this is underrecognized as a key issue in our specialty. This review synthesizes the current literature on the complex relationship between climate change and dermatologic conditions, specifically focusing on four key areas: UV exposure, infectious dermatoses, impact on vulnerable populations, and medical waste. Rapidly rising temperatures and ozone layer depletion directly correlate with increased UV exposure, thereby increasing the risk of skin cancer and photosensitive dermatoses. Climate change ultimately alters both vector and microbial survival, thus expanding the geographic ranges of pathogens and, through extreme weather and human migration, fostering the emergence of both known and novel infectious dermatoses. Vulnerable populations are disproportionately bearing the brunt of these dermatologic consequences due to various structural inequities. Finally, dermatologic practices generate waste that contributes to climate change, and while the use of artificial intelligence (AI) in dermatology has exciting and innovative applications, developers and users should be mindful of the environmental impact and prioritize sustainable strategies when possible.
subject: Review Article
  topic: section
subject: artificial intelligence
  topic: keywords
subject: climate change
  topic: keywords
subject: dermatology
  topic: keywords
subject: dermatoses
  topic: keywords
subject: infectious
  topic: keywords
subject: medical waste
  topic: keywords
subject: ozone depletion
  topic: keywords
subject: skin cancer
  topic: keywords
subject: ultraviolet
  topic: keywords
subject: vulnerable populations
  topic: keywords
creator: Laura Clarke, BS
creator: Morelle Heiden, BS
creator: Andrea M Rustad, MD
creator: Apple Bodemer, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-05-11
publication date: 2026-05-11
doi: 10.64550/joid.0w25wk27

Introduction of Oral Probiotics for Symptom Reduction in Pediatric Atopic Dermatitis: A Prospective Pilot Study
type: item
description: # Relevance Atopic dermatitis is a chronic inflammatory skin condition that significantly affects quality of life in children and families. Increasing interest in integrative approaches has led to investigation of probiotic supplementation as a potential adjunctive therapy. # Objective To evaluate the clinical impact of daily oral probiotic supplementation in children with sub-optimally controlled atopic dermatitis in a pediatric primary care setting. # Methods This prospective single-arm pilot study enrolled children aged 0–15 years with clinician-diagnosed atopic dermatitis and persistent symptoms. Participants initiated daily oral probiotic supplementation for 12 weeks. Symptom severity was assessed using the Patient-Oriented Eczema Measure (POEM) at baseline and at 4-, 8-, and 12-week follow-up. The primary outcome was change in POEM score from baseline to week 12. Descriptive statistics were used to evaluate symptom change and adherence. # Results Seventeen participants completed the 12-week intervention. Mean baseline POEM score decreased from 10.41 to 3.7 at week 12 (mean change −6.74), corresponding to a mean percent improvement of 64%. Fourteen participants (82%) demonstrated reduction in POEM score. Adherence (≥5 days per week) was observed in 76% of participants. One participant reported mild gastrointestinal discomfort; no serious adverse events occurred. # Conclusion Daily oral probiotic supplementation was associated with meaningful reductions in patient-reported atopic dermatitis symptoms in this pilot cohort. These findings support further controlled studies evaluating probiotics as an adjunctive strategy in pediatric atopic dermatitis management.
subject: Original Research
  topic: section
subject: Eczema
  topic: keywords
subject: probiotics
  topic: keywords
subject: Pediatrics
  topic: keywords
subject: Skin
  topic: keywords
subject: Children
  topic: keywords
subject: Non-pharmacologic
  topic: keywords
subject: Atopic dermatitis
  topic: keywords
subject: Patient Oriented
  topic: keywords
creator: Christie Potter, DNP, APRN, CPNP-PC
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-05-01
publication date: 2026-05-01
doi: 10.64550/joid.2s295s83

Hidradenitis Suppurativa Subtypes: Exploring Proposed Phenotypes and Their Clinical Relevance
type: item
description: Hidradenitis suppurativa (HS) is a multi-factorial disease with a wide range of presentations. Several classification systems have attempted to define unique phenotypes, aiming to guide clinical management and elucidate underlying mechanisms. However, overlapping features limit their practical utility. We reviewed existing literature and consolidated key features into four clinical domains: weight, smoking, atypical site involvement, and inflammatory load. By considering these factors, clinicians can adopt a more individualized, integrative approach to HS management. We recommend clinicians discuss weight management and smoking cessation with all HS patients. For pharmacological management, atypical site involvement, a moderate to severe assessment with HS-IGA (Hidradenitis Suppurativa Investigator Global Assessment), and a high HiSQoL (Hidradenitis Suppurativa Quality of Life) score may warrant early systemic therapy to control disease progression and reduce long-term complications.
subject: Review Article
  topic: section
subject: Hidradenitis Suppurativa
  topic: keywords
subject: Phenotypes
  topic: keywords
subject: Subtypes
  topic: keywords
subject: Integrative Dermatology
  topic: keywords
creator: Ajay S. Dulai, MBBS, MSc
creator: Elham T. Tabatabaei, MD
creator: Raja K. Sivamani, MD,MS
creator: Steven Daveluy, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-04-01
publication date: 2026-04-01
doi: 10.64550/joid.eax2yv29

Beyond Hot Flashes: Understanding and Treating Menopause-Associated Skin Changes
type: item
description: Menopause represents a pivotal physiological transition with profound dermatologic implications. Declining estrogen and shifts in other sex hormones trigger a spectrum of cutaneous and hair changes, including dryness, pruritus, impaired barrier function, acne, rosacea, hair thinning, increased facial hair, and accelerated skin aging. These manifestations extend beyond cosmetic concerns, contributing to discomfort, reduced quality of life, and increased vulnerability to inflammatory and infectious dermatoses. This review examines the underlying mechanisms of menopause-associated skin and hair changes and highlights current and emerging therapeutic strategies to inform clinical management. Estrogen plays a central role in dermal and follicular homeostasis through collagen, elastin, water retention, and ceramide regulation. As such, estrogen deficiency contributes to collagen loss, impaired barrier integrity, reduced elasticity, and increased transepidermal water loss—exacerbating xerosis and skin sensitivity. Hormonal shifts, including relative androgen excess, further contribute to acne, sebaceous gland activity, and unwanted hair growth. Moreover, barrier dysfunction and immune dysregulation may worsen existing dermatologic conditions, underscoring the complexity of menopause-related skin changes. Emerging therapeutic options are evolving beyond systemic and topical hormone replacement therapy, as their use is limited by systemic risks. Alternative and adjunctive approaches, including selective estrogen receptor modulators, topical retinoids, antioxidants, phytoestrogens, and regenerative options such as exosomes, offer promising, targeted options for postmenopausal skin management. Given the high prevalence of dermatologic and hair concerns during menopause and the postmenopausal period, heightened awareness, evidence-based treatment strategies, and continued research are essential. Understanding the multifactorial pathophysiology of menopause-associated skin chang…
subject: Original Research
  topic: section
subject: Menopause
  topic: keywords
subject: Women
  topic: keywords
subject: Skin Aging
  topic: keywords
subject: Skin Changes
  topic: keywords
subject: Estrogen
  topic: keywords
subject: Hormone Replacement Therapy
  topic: keywords
subject: Selective Estrogen Receptor Modulators
  topic: keywords
subject: Phytoestrogens
  topic: keywords
subject: Exosomes
  topic: keywords
subject: Hormones
  topic: keywords
creator: Alana Sadur, BS
creator: Aniket Asees, BS
creator: Mana Nasseri, BS
creator: Mina Farah, BS
creator: Savanna I Vidal, BS
creator: Nikita Menta, BA
creator: Jenny Murase, MD
creator: Sonal Choudhary, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-31
publication date: 2026-03-31
doi: 10.64550/joid.jzw4me05

Cyano-Phycocyanin: A Potential Photoprotective Nutraceutical to Reduce Ultraviolet Radiation-Induced Damage and Skin Cancer Risk
type: item
description: # Purpose Antioxidant supplementation has been clinically proven to prevent tissue damage and boost repair mechanisms by mitigating oxidative stress. This article aims to achieve an in-depth understanding of Cyano-Phycocyanin's (C-PC)’s mechanism of action and overall benefits after exposure to ultraviolet radiation (UVR) from the sun. C-PC, a phycobiliprotein extracted from nutrient-dense, safe-to-consume blue-green algae known as Spirulina or Arthrospira platensis (AP), is considered a “superfood” due to its exceptional nutritional profile and bioactive properties. C-PC’s potent antioxidant and anti-inflammatory benefits are well-known to promote tissue repair and overall health. UVR accounts for approximately 80-90% of skin environmental aging and is the leading cause of skin cancer (non-melanoma and melanoma). Thus, our hypothesis suggests that C-PC supplementation as an adjunct photoprotective therapy may help prevent or diminish intrinsic and/or environmental aging linked to UVR and the tumorigenicity of UVR. # Method A PubMed, Clinical Key, and Cochrane Library literature search was conducted using the following search terms: cyano-phycocyanin, spirulina, antioxidant, free-radical damage, ultraviolet radiation, oxidative stress, and skin cancer. Twenty pertinent articles were retrieved as the basis for this clinical review. # Results Robust in vitro and animal models evidence-based research showed a positive correlation between C-PC supplementation, and cellular protection suggesting a potential role in skin cancer protection. # Conclusion C-PC in vivo and in vitro research indicates promising results in repairing and reversing cellular damage. However, while preclinical data is compelling, human clinical evidence is still pending to determine the level of benefit linked to oral supplementation with C-PC.
subject: Review Article
  topic: section
subject: Spirulina
  topic: keywords
subject: Antioxidant
  topic: keywords
subject: Anti-inflammatory
  topic: keywords
subject: Oxidative stress
  topic: keywords
subject: Free-Radical Damage
  topic: keywords
subject: Skin Damage
  topic: keywords
creator: Renata Block, DMSc, MMS, PA-C
creator: Sara Wilchowski, DMSc, PA-C
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-20
publication date: 2026-03-20
doi: 10.64550/joid.7fzwnd94

Reframing Dermatologic Disease Through Trauma, Attachment, and Autonomic Science: An Integrated Biopsychosocial Framework for Clinical Practice
type: item
description: Chronic skin disease is commonly explained through immune dysregulation, barrier impairment, and genetic risk, yet growing evidence indicates that stress physiology, early adversity, and relational experience also shape dermatologic vulnerability and symptom expression. Research from neuroscience, psychoneuroimmunology, trauma studies, and attachment science demonstrates that autonomic regulation and early relational environments influence inflammatory responses, sensory processing, and the chronicity of multiple skin conditions. Because the skin and nervous system share an ectodermal origin, they maintain continuous bidirectional communication across the lifespan. Nervous system signals regulate cutaneous inflammation, barrier repair, pruritus, and nociception, while the skin functions as a neuroimmunoendocrine organ capable of producing and responding to stress mediators. These pathways contribute to “skin memory,” reflected in autonomic tone, inflammatory thresholds, and stress-reactive sensory profiles. Consequently, cutaneous responses represent systemic nervous system patterns rather than isolated local events. This Perspective introduces the Somatic Skincare™ Method as a clinical framework integrating autonomic regulation, relational safety, and affective touch with conventional dermatologic care. Trauma-informed, nervous system–aware approaches may reduce shame, enhance coping strategies, and improve symptoms not fully addressed by medical therapy alone. This synthesis reframes dermatologic disease as a biologically and relationally embedded process and proposes an expanded model for assessment, patient education, and therapeutic intervention within integrative dermatology.
subject: Perspective, Opinion, Commentary
  topic: section
subject: Psychodermatology
  topic: keywords
subject: Neuroimmunoendocrine skin
  topic: keywords
subject: Autonomic dysregulation
  topic: keywords
subject: Adverse childhood experiences
  topic: keywords
subject: Attachment and skin
  topic: keywords
subject: Stress physiology
  topic: keywords
subject: Neurogenic inflammation
  topic: keywords
subject: Somatic Skincare™ Method
  topic: keywords
subject: Mind-skin connection
  topic: keywords
subject: Integrative dermatology
  topic: keywords
subject: Polyvagal theory
  topic: keywords
creator: Keira Barr, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-18
publication date: 2026-03-18
doi: 10.64550/joid.ecmwga85

Calming the Itch: Evidence-Based Non-pharmacologic Interventions for Chronic Pruritus
type: item
description: Chronic pruritus, defined as itch lasting more than six weeks, affects up to 22% of individuals during their lifetime and carries a substantial burden, including impaired sleep, reduced quality of life, and increased risk of depression. Conventional pharmacologic therapies often provide only partial or temporary relief, particularly when itch arises from neuropathic or psychogenic causes, highlighting the need for complementary strategies. This review examines evidence for non-pharmacologic interventions, which can be grouped into neuromodulation, mind-body approaches, and barrier or environmental strategies. Neuromodulatory options such as phototherapy, transcutaneous electrical nerve stimulation (TENS), cryotherapy, heat therapy, and acupuncture act on neural pathways. Of these, narrowband ultraviolet B (NB-UVB) phototherapy has the strongest evidence, consistently improving itch and reducing corticosteroid use. Mind-body interventions, including cognitive behavioral therapy (CBT), meditation, relaxation training, music therapy, and massage, target the perception of itch and the itch-scratch cycle, with benefits most evident in atopic dermatitis (AD). Barrier-focused therapies such as antimicrobial textiles and wet-wrap treatment enhance hydration, restore skin integrity, and may provide rapid relief, particularly in pediatric AD. Despite encouraging findings, most trials are small, short-term, and heterogeneous. These therapies should be considered supportive adjuncts to standard care, with larger controlled studies needed to establish long-term efficacy.
subject: Review Article
  topic: section
subject: Pruritus
  topic: keywords
subject: Itch
  topic: keywords
subject: Non-pharmacologic
  topic: keywords
subject: TENS
  topic: keywords
subject: Phototherapy
  topic: keywords
subject: Mind-body
  topic: keywords
subject: Acupuncture
  topic: keywords
subject: Cryotherapy
  topic: keywords
creator: Duncan MacIntyre, BS
creator: Peter Lio, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-17
publication date: 2026-03-17
doi: 10.64550/joid.x3nm1829

One Oral Dermatologic Supplement with Two Indications? A Review of Active Ingredients in Popular Hair Supplements and Their Efficacy in Treating Hair Loss and Acne
type: item
description: The use of oral supplements in the treatment of dermatologic conditions has been increasing. These supplements often contain a combination of vitamins, minerals, and botanicals. They are advertised to treat various conditions, including hair and skin disorders. Given the overlap in ingredients, this review explores whether a single oral supplement could effectively address multiple dermatologic conditions, even if not specifically advertised. A Google search was performed for “hair growth supplements.” The top results were reviewed with documentation of active ingredients, and then a literature search was performed for each ingredient’s role in hair and acne management. Results showed that vitamins A, C, D, and E, as well as biotin, zinc, and selenium, demonstrated mixed efficacy in treating hair loss and acne, while iodine supported hair growth but was associated with worsening acne. By synthesizing the current data, clinicians can help consumers make more informed decisions and gain a clearer understanding of the supplements they use.
subject: Review Article
  topic: section
subject: Hair growth
  topic: keywords
subject: Oral supplements
  topic: keywords
subject: Acne vulgaris
  topic: keywords
creator: Amanda Hunt, MD
creator: Victoria Kuritza, MD
creator: Peter Lio, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-17
publication date: 2026-03-17
doi: 10.64550/joid.r5452r70

An Overview of Hyperhidrosis Treatment Options with an Emphasis on Iontophoresis as a Non-invasive, Effective, and Safe Treatment Modality
type: item
description: # Relevance Hyperhidrosis, a condition characterized by excessive sweating beyond physiological needs, most commonly affects adolescents and young adults aged 18-39, though it can also present in pediatric populations. Approximately 15.3 million people in the United States, about 4.8% of the population, are affected. Despite its prevalence, evidence remains limited for many treatment modalities, particularly iontophoresis. # Objectives The purpose of this manuscript is to review the general treatment options for hyperhidrosis, with a specific focus on iontophoresis as an integrative approach. # Methods A comprehensive literature search was conducted using PubMed, Google Scholar, and the University of Wisconsin Libraries. Search terms included various combinations of keywords such as “hyperhidrosis”, “primary and secondary hyperhidrosis”, “treatment management”, “quality of life”, “prevalence”, “antiperspirants”, “iontophoresis” (including its mechanisms and guidelines), “botulinum toxin”, “anticholinergics”, “MiraDry”, “surgical management”, “psychological impact”, and “supplement.” Studies were selected based on their relevance to the pathophysiology and therapeutic applications of hyperhidrosis, with no restrictions on publication date or language. # Results Treatment options for hyperhidrosis include topical antiperspirants, topical anticholinergics, oral anticholinergics, botulinum toxin injections, surgical sympathectomy, microwave-based treatment, iontophoresis, multidisciplinary care and supplements. Iontophoresis is considered a first-line, non-invasive treatment for palmar and plantar hyperhidrosis. It may also be used for axillary hyperhidrosis when compatible machines with specialized attachments are available. The procedure involves immersing the affected areas, typically the hands or feet, most commonly in tap water or medicated solutions such as aluminum salts, glycopyrrolate, glycopyrronium bromide, or poldine methosulfate while a mild electrical curr…
subject: Review Article
  topic: section
subject: Hyperhidrosis
  topic: keywords
subject: Primary Hyperhidrosis
  topic: keywords
subject: lontophoresis
  topic: keywords
subject: Secondary Hyperhidrosis
  topic: keywords
subject: Palmar and plantar hyperhidrosis
  topic: keywords
subject: Non-invasive treatment modality
  topic: keywords
subject: MiraDry
  topic: keywords
subject: Psychological Impact
  topic: keywords
creator: Simran Kaur, MD
creator: Jacqueline Kieu, BS
creator: Andrea M. Rustad, MD
creator: Apple A. Bodemer, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-17
publication date: 2026-03-17
doi: 10.64550/joid.n4jgga70

https://dev.jintegrativederm.org/index.php/joid/article/view/134
type: item
title: Open-Label Study Demonstrating Improvement in Atopic Dermatitis and Pruritus Resulting from the Use of an Oral Antioxidant-Enhanced L-Histidine Supplement with a Plant-Biotech Moisturizer and Unscented Soap
description: # Relevance Atopic dermatitis (AD) is an inflammatory skin condition with a multifactorial pathophysiology. Standard treatment emphasizes topical corticosteroids (TCs), but there is growing interest in alternatives to TCs. # Objective To evaluate the efficacy of a novel antioxidant-enhanced L-histidine supplement, a plant-biotech moisturizer, and an unscented soap on AD severity, pruritus, and skin biophysical properties. # Methods An open-label trial was conducted including 35 subjects with moderate AD. At baseline and day 56, the SCORAD, pruritus, mood changes, and skin biophysical measures were assessed. # Results Between D0 and D56, mean total SCORAD decreased by 93% (p<0.0001), mean oSCORAD decreased by 92.1% (p<0.0001), and mean p-NRS decreased by 97% (p<0.0001). By D56, TEWL decreased by 29% (p=0.002), hydration increased by 117% (p<0.0001), and desquamation index decreased by 83% (p<0.0001). In addition, when mood was assessed at D56 relative to baseline, there were significant reductions in overall negative affect (p<0.05). # Conclusion The oral supplement, plant-biotech moisturizer, and unscented soap demonstrated improvement in skin barrier integrity and AD severity in 8 weeks, suggesting potential clinical efficacy of plant-biotech for AD management.
subject: Original Research
  topic: section
subject: Antioxidant
  topic: keywords
subject: I-histidine
  topic: keywords
subject: SCORAD
  topic: keywords
subject: Nutraceutical
  topic: keywords
subject: Cosmeceutical
  topic: keywords
creator: Barbara Paldus, PhD
creator: Jessica Maloh, ND
creator: Ewa Karamon, MD
creator: Zill-e-huma Khan, MD
creator: Mildred Min, MD
creator: Ajay S. Dulai, MBBS
creator: Peter A. Lio, MD
creator: Mark Selker, PhD
creator: Marc Cornell
creator: Raja K. Sivamani, MD, MS, AP
creator: Philippe Humbert, MD, PhD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-13
publication date: 2026-03-13
doi: 10.64550/joid.ymnj5r09

From the Kitchen to Your Skin: A Review of Nontraditional Moisturizers
type: item
description: In recent years, consumers have become more aware of the ingredients used in their daily personal care products. Added colorants, fragrances, and preservatives have raised concerns about safety. Due to this, there has been increased interest online to identify integrative moisturizers for use in consumers’ routines. This review investigates nontraditional moisturizers studied in the literature and reports on their proposed mechanism of action, clinical efficacy, and potential side effects. Studies were identified through searches on PubMed, Google, and Google Scholar using a broad range of search terms. Findings show many of these agents can decrease transepidermal water loss, support skin barrier function, and deliver essential nutrients to skin. Future studies are needed to investigate these products for specific use as skin moisturizers in a wide range of skin types to evaluate their application in clinical practice. By synthesizing the current data, consumers can make well-informed decisions, and these products can help diversify skincare ingredients, offering more easily accessible and cost-effective options.
subject: Review Article
  topic: section
subject: Integrative skincare
  topic: keywords
subject: Moisturizer
  topic: keywords
subject: Plant oils
  topic: keywords
subject: Tallow
  topic: keywords
subject: Vegetable shortening
  topic: keywords
subject: Beeswax
  topic: keywords
subject: Honey
  topic: keywords
subject: Emu oil
  topic: keywords
creator: Amanda Hunt, M.D.
creator: Victoria Kuritza, M.D.
creator: Peter Lio, M.D.
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-13
publication date: 2026-03-13
doi: 10.64550/joid.4vvarv96

Insulin resistance in Mexican women with acne vulgaris
type: item
description: # Relevance Acne vulgaris is the most common dermatological condition defined as a chronic inflammatory disease of the pilosebaceous unit. Insulin could be part of the pathophysiology of acne through various mechanisms. # Objective To determine the prevalence of insulin resistance in female patients with acne vulgaris. # Methods We designed a descriptive observational study, in which we included a sample of 319 women with acne vulgaris. The diagnosis was established clinically by a dermatologist. Clinical data and biochemical parameters of serum insulin, fasting glucose, HOMA-IR and lipid profile were evaluated. # Results 319 women diagnosed with acne vulgaris were included, with a mean age of 30.45 years ± 0.37 (18-69). 82.8% (264) of them were over 25 years old, classified as adult female acne. Laboratory results were: mean serum insulin 16.83±0.43 (2.61-54.30), mean glucose 90.74±0.83 (69-304), HOMA-IR 3.82±0.11 (0.53-14.08), and mean total cholesterol 173.92±1.88 (100-303). Of the 319 patients, 317 of them (99.37%) had a HOMA-IR >1.22. # Conclusion Insulin resistance is underdiagnosed. It is essential that dermatologists diagnose and treat it promptly to improve the response to treatment and avoid the development of metabolic and cardiovascular complications.
subject: Original Research
  topic: section
subject: Acne vulgaris
  topic: keywords
subject: Insulin resistance
  topic: keywords
subject: HOMA-IR
  topic: keywords
creator: Denisse Islas Cortes, M.D.
creator: Patricia Carmona, M.D
creator: Eduardo Chuquiure Valenzuela, MHSc, M.D
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-12
publication date: 2026-03-12
doi: 10.64550/joid.gms4z955

Indigo Naturalis in Dermatology: Current Evidence and Clinical Applications
type: item
description: Indigo naturalis (IN) is a dried, dark blue powder derived from the leaves and stems of plants such as _Baphicacanthus cusia Bremek_., _Polygonum tinctorium Aiton_, and _Isatis indigotica Fort_. Aside from its prominent use in textiles due to its rich blue color, IN was used to treat a variety of medical conditions such as hemoptysis, epistaxis, chest pain, sore throats, oral ulcers, and infantile convulsion. Modern research has isolated many active compounds from IN, which have been found to exhibit a wide range of biologic activities, including antiviral, antibacterial, anti-inflammatory, antiangiogenic, antioxidant, and immune modulating effects. These pharmacologic properties have sparked growing interest in evaluating the efficacy and safety of IN-based therapies for a variety of dermatologic conditions. While the current literature on the dermatologic applications of IN is still developing, its pharmacologically active compounds and early clinical findings point to significant potential for future investigation. This review examines some of that literature from a clinical perspective.
subject: Review Article
  topic: section
subject: Indigo Naturalis
  topic: keywords
subject: Botanical
  topic: keywords
subject: Psoriasis
  topic: keywords
subject: Atopic dermatitis
  topic: keywords
subject: Pityriasis rosea
  topic: keywords
subject: Anti-inflammatory
  topic: keywords
creator: Joseph Zourob, BS
creator: Peter Lio, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-10
publication date: 2026-03-10
doi: 10.64550/joid.s4x2mw93

Healing from the Desert: Southwestern U.S. Indigenous Botanicals for Inflammatory Skin Conditions
type: item
description: # Relevance For millennia, Indigenous communities of the American Southwest have used native plants to treat skin inflammation, wounds, and infections. Despite this rich ethnobotanical knowledge, many of these therapies remain underrepresented in dermatologic literature and practice. # Objective This review bridges traditional Indigenous use and modern scientific validation of four Southwestern botanicals, Larrea tridentata (chaparral), Yucca spp., Juniperus monosperma (desert cedar), and Aloe vera, with established or emerging applications in inflammatory skin conditions. # Methods A structured literature search was conducted across biomedical and ethnobotanical databases (PubMed, Scopus, ScienceDirect, Google Scholar, AnthroSource). Inclusion criteria prioritized topical use, Indigenous documentation, Southwestern U.S. origin, and relevance to dermatology. Extracted data were organized into four categories: traditional use, phytochemistry, mechanisms of action, and safety. # Results All four botanicals demonstrated convergent support between traditional applications and biomedical findings. Larrea tridentata exhibits potent antioxidant and anti-inflammatory activity via nordihydroguaiaretic acid, though systemic toxicity limits internal use. Yucca spp. deliver saponins and flavonoids that suppress NF-κB and MAPK pathways, reduce cytokines, and combat microbial infections. Juniperus monosperma, rich in thujone, α-pinene, and bornyl acetate, demonstrates antimicrobial and anti-inflammatory activity, with caution warranted due to potential neurotoxicity in high concentrations. Of the four botanicals studied, Aloe vera shows the most robust clinical evidence for wound healing, eczema, and psoriasis, with key compounds like acemannan and aloin supporting epithelial regeneration and cytokine modulation. # Conclusion Southwestern Indigenous botanical therapies for skin inflammation are increasingly supported by molecular and clinical evidence. Integrating these therapies…
subject: Review Article
  topic: section
subject: Ethnobotany
  topic: keywords
subject: Inflammatory skin
  topic: keywords
subject: Indigenous medicine
  topic: keywords
subject: Larrea tridentata
  topic: keywords
subject: Yucca
  topic: keywords
subject: Juniperus monosperma
  topic: keywords
subject: Aloe vera
  topic: keywords
subject: Southwestern united
  topic: keywords
subject: Integrative dermatology
  topic: keywords
creator: Andres Parga, MD
creator: Hannah Coven, R.D.N, M.S.
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-09
publication date: 2026-03-09
doi: 10.64550/joid.c9bww556

The Impact of Social Media Influencers on Skincare Behaviors Among Skin of Color Populations: A Narrative Review (2015-2025)
type: item
description: Social media influencers have become key sources of skincare advice for skin-of-color (SOC) communities in the U.S., often bridging gaps in representation and cultural relevance within dermatology. These digital platforms offer accessibility and relatability that many SOC individuals feel is lacking in traditional care. However, influencer content remains largely unregulated, raising concerns about misinformation, cultural insensitivity, and disparities in digital health literacy. This scoping review explores how influencer-driven skincare content affects dermatologic engagement among SOC audiences. We analyzed 36 peer-reviewed studies published between 2015 and 2025, identified through PubMed and Google Scholar using SOC- and dermatology-focused search terms. Only U.S.-based research targeting SOC populations was included. Inductive thematic analysis revealed key trends, and thematic saturation was reached by the 30th study. Findings show that 42–59% of SOC individuals rely on influencers for skincare guidance, often due to cost, accessibility, and the lack of culturally competent care. Yet, misinformation was common: over 50% of influencer content on hyperpigmentation promoted unsafe hydroquinone use, and 12% included harmful DIY remedies. Spanish-language content showed significantly higher error rates, and 62% of hijabi influencers recommended non-halal products. While dermatologist-created content was more accurate, it lacked reach and engagement. Influencers serve an important role by making skincare more inclusive, but the risks of misinformation and cultural mismatch are substantial. To improve outcomes, stronger collaborations between influencers and dermatologists, increased accountability from platforms, and culturally tailored communication strategies are essential to meet the needs of SOC communities.
subject: Review Article
  topic: section
subject: Skin of color
  topic: keywords
subject: Dermatology
  topic: keywords
subject: Influencers
  topic: keywords
subject: Social Media
  topic: keywords
subject: Misinformation
  topic: keywords
subject: Hyperpigmentation
  topic: keywords
subject: Cultural competence
  topic: keywords
subject: Health disparities
  topic: keywords
subject: Digital health literacy
  topic: keywords
subject: skincare communication
  topic: keywords
creator: Gaity Wahab, BS
creator: Kailey Bae, BA
creator: Annalise Cooper, MS
creator: Edwine Coulanges, MS
creator: Mary-Pascale Pericles, MPH
creator: Nabeeha Soherwardy, BS
creator: Caroline Aprigliano, BS
creator: Harleen Dhami, BS
creator: Danny Lee, MD
creator: Carlene Radix, MD, MPH
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-07
publication date: 2026-03-07
doi: 10.64550/joid.1xq2a607

Practical Pain-Free Dermatology: A Review of Evidence-Based Approaches to Minimizing Procedural Discomfort
type: item
description: # Background Procedural pain remains a major barrier in dermatologic care, often influencing whether patients pursue treatment and impacting overall satisfaction and even procedural success. While some have embraced a range of evidence-based pain management strategies, overall dermatology has many unmet needs in consistent implementation and research. # Objective This narrative review aims to summarize and evaluate current evidence-based pharmacologic and non-pharmacologic strategies used to minimize procedural pain in dermatology and highlight the need for broader adoption, in both pediatric and adult care. # Methods A comprehensive literature review was conducted using PubMed to identify studies published from May 2015 to the present, focusing on clinically relevant pain management strategies in dermatologic procedures. In addition to database searches, reference lists of key articles were reviewed to identify further relevant studies. Included sources were selected based on their clinical applicability and contribution to the understanding of procedural pain management. Results were categorized into pharmacologic methods (e.g., anesthetics) and nonpharmacologic approaches (e.g., distraction, sensory modulation). # Results Liposomal formulations of lidocaine demonstrate improved onset and absorption compared to traditional agents. Nonpharmacologic techniques—including virtual reality, noise-canceling headphones, vibration, cooling sprays, music, and aromatherapy—were also effective, particularly in pediatric patients. However, there is a lack of standardized implementation in adult dermatology. Studies support the potential for combining pharmacologic and non-pharmacologic approaches for enhanced results. # Conclusion Effective pain control improves comfort, satisfaction, and possibly even treatment success in procedures. While pediatric dermatology is often guided by more structured protocols, care in adult dermatology may be less uniform across practices. Future…
subject: Review Article
  topic: section
subject: Pain
  topic: keywords
subject: Lidocaine
  topic: keywords
subject: Aromatherapy
  topic: keywords
subject: Distraction
  topic: keywords
subject: Anesthesia
  topic: keywords
creator: Jennifer Keelin, BS
creator: Peter Lio, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-03-03
publication date: 2026-03-03
doi: 10.64550/joid.4jffz731

Milk and Skin: A Narrative, Integrative Review of Dairy and Dairy Substitutes Through the Lens of Cutaneous Inflammation
type: item
description: Nutrition influences pathophysiology in acne and many cutaneous inflammatory disorders. Milk and milk products may worsen inflammation via multiple mechanisms. Recent syntheses on diet and acne, alongside reviews of vegan/plant‑forward approaches, justify addressing these questions in dermatology practice. An integrative, patient-centered approach, utilizing short-term trials, objective tracking, and balanced communication is proposed given the heterogeneity of studies and many remaining questions.
subject: Perspective, Opinion, Commentary
  topic: section
subject: Acne vulgaris
  topic: keywords
subject: Dairy
  topic: keywords
subject: Plant-based milk
  topic: keywords
subject: IGF-1
  topic: keywords
subject: mTORC1
  topic: keywords
subject: Microbiome
  topic: keywords
subject: Integrative Dermatology
  topic: keywords
creator: Jennifer Keelin, BS
creator: Peter Lio, MD
rights: Copyright (c) 2025 Journal of Integrative Dermatology
date: 2026-02-27
publication date: 2026-02-27
doi: 10.64550/joid.kcfbqe72